Endocrine Abstracts

A 71-year-old gentleman was referred for investigation of bilateral enlarged adrenals first discovered after presenting with subacute bowel obstruction. A CT scan of his abdomen revealed the left adrenal was 8×5 cm, the right 3 cm. No other abnormalities were detected.The patient was otherwise well. No other medical history was volunteered. On examination, he was of short stature (height 1.47 m) with a normal pattern of pubic and axillary hair. Bloo...

Objective: An interaction between adiponectin, steroid synthesis or action and measures of insulin resistance (IR) have been reported in the pathogenesis of polycystic ovary syndrome (PCOS). The present study was done to determine plasma adiponectin concentration (PAC) in women with and without PCOS and to assess its correlation to the hormonal and metabolic parameters including measures of IR. The effect of metformin for 6 months in PCOS was also evaluated.<p class="abste...

The aim of this study was to determine the changes of cortisol and T3 (triiodothyronine) levels in Acanthopagrus latus, a marine euryhaline teleost, in response to a wide range of salinities. The first experiment was carried out following exposure of juvenile yellowfin seabream to 5, 20, 42 and 60‰ environments. In the second experiment, the fish were assigned to a gradual adaptation to freshwater. Yellowfin seabream was capable of tolerating direct ex...

Background: Disturbance of thyroid hormones metabolism and morphology is common in ESRD (end stage renal disease) but there are discrepancies between data after transplantation. The aim of this study was assessment of the thyroid function and morphology after renal transplantation surgery.Material and method: All recipient patients, without previous history of thyroid disorders, were enrolled. Serum level of creatinine, total T3 and T4 (TT3, TT4), resin ...

Patients with Cushing's disease are well known to develop easy bruising due to cortisol excess but are also predisposed to thrombembolism.We present four patients who developed thromboembolism during active Cushing's disease.Case 1- Four year history of hypertension, osteoporosis and central obesity. A DVT developed prior to referral. Initial urinary free cortisol(UFC)was 524nmol/24hrs. Inferior petrosal sinus sampling indicated ...

Much less information is available on the thyroid hormones at different age groups, laying, non-laying and methimazole (MMI) treated japanese quails. All birds were kept under 14:10 hour light schedule and were provided feed and water adlibitum. Fifteen japanese quailsin each age groups, laying, non-laying and MMI treated were decapitated for collection of plasma. Thyroid hormones (T3 and T4) were estimated using ELISA commercial kits. The results showed that plasma thyroid ho...

Eight healthy pregnant goats, aged 2-4 years, were selected for this study. Blood samples were obtained in tubes containing EDTA at different stages of pregnancy, at parturition and on days 1, 7 and 14 postpartum. Blood from foeti was also collected on days 1 and 7 after their birth. Plasma was separated, frozen at -20 celsius till analysed for thyroid hormones (T3 and T4) using ELISA comercial kits. Thyroxine (T4) concentration was higher during prepartum, decreased significa...

BackgroundPrevalence of hypogonadism has been reported as high as 50% in men with T2DM and/or obesity. ADA and AACE Guidelines recommend assessment of hypogonadism in men with T2DM and obesity.Material and methodsIn a registry of 865 men with hypogonadism, 361 men (41.7%) had T2DM. 183 received TU 1000 mg/12 weeks (T-group), 178 opted against treatment (CTRL). Changes over time between groups were compared an...

BackgroundWhile almost all studies consistently show reduction of waist circumference as a result of testosterone therapy (TTh), effects on body weight are inconsistent and may depend on treatment duration, route of administration, and adherence.Material and methodsAfter excluding men with primary hypogonadism, 476 men with functional, symptomatic hypogonadism were obese. 281 men received testosterone undecan...

BackgroundEffects of testosterone therapy (TTh) on lipid parameters are inconsistent and may depend on treatment duration, route of administration, and adherence. While in short-term studies, testosterone usually lowers HDL, long-term studies seem to increase HDL. Total cholesterol, LDL and triglycerides are either reduced by TTh, or effects are neutral.Material and methodsAfter excluding men with primary hyp...